Torra M, Rodamilans M, Corbella J
Toxicology Unit, Hospital Clinic and Provincial, University of Barcelona, Spain.
Sci Total Environ. 1998 Sep 4;220(1):81-5. doi: 10.1016/s0048-9697(98)00248-4.
Serum and urine fluoride levels were determined in 250 healthy subjects (15-90 years, 122 men and 128 women) residing in Catalonia, Spain, and in 150 patients (20-81 years, 84 men and 66 women) with chronic renal failure undergoing regular dialysis treatment, living in the same geographical area, to determine normal range and to investigate its relationships to age, sex and renal function. Serum and urine fluoride were determined by a fluoride ion specific electrode system. Mean (+/- S.D.) serum fluoride concentration was 17.5 +/- 9.5 micrograms/l, ranging from 1 to 47 micrograms/l, in the control group and 58 +/- 31 micrograms/l, ranging from 28 to 185 micrograms/l, in renal patients. Urine fluoride concentration in the healthy group was 671 +/- 373 micrograms/24 h, ranging from 156 to 1900 micrograms/24 h. Fluoride status in the patient group was significantly greater than the control group. There was significant correlation between serum fluoride and age. No sex related difference was found.
对居住在西班牙加泰罗尼亚地区的250名健康受试者（年龄在15至90岁之间，男性122名，女性128名）以及150名患有慢性肾衰竭且正在同一地理区域接受定期透析治疗的患者（年龄在20至81岁之间，男性84名，女性66名）测定了血清和尿液中的氟含量，以确定正常范围，并研究其与年龄、性别和肾功能的关系。血清和尿液中的氟通过氟离子特异性电极系统进行测定。对照组的平均（±标准差）血清氟浓度为17.5±9.5微克/升，范围为1至47微克/升；肾病患者组的血清氟浓度为58±31微克/升，范围为28至185微克/升。健康组尿液氟浓度为671±373微克/24小时，范围为156至1900微克/24小时。患者组的氟水平显著高于对照组。血清氟与年龄之间存在显著相关性。未发现性别相关差异。
