Singer L, Ophaug R H
Clin Chem. 1979 Apr;25(4):523-5.
We found no significant difference between the means for ionic, bound, and total fluoride concentrations in the plasma of male and female subjects of the same age, living in a community with fluoridated water. When results for the 264 fasting subjects were therefore combined according to age, they indicated that persons over 60 years of age have a significantly higher mean ionic (3.89 mumol/L) and total (6.58 mumol/L) fluoride concentration in plasma than do younger age groups. For younger age groups, means ranged from 2.74 to 3.05 mumol/L for ionic fluoride and from 4.74 to 5.58 mumol/L for total. The bound fluoride concentration was lower in individuals 21 to 30 years of age (1.89 mumol/L) than in older age groups (for whom means ranged from 2.42 to 2.68 mumol/L), but was not significantly different from that of individuals who were younger (2.21 mumol/L). A tendency for the mean ionic fluoride concentration to increase with age was noted, but the concentration was significantly higher than the preceding decade group only in those persons over 60 years of age.
我们发现，在饮用含氟水的社区中，相同年龄的男性和女性受试者血浆中离子氟、结合氟和总氟浓度的平均值之间没有显著差异。因此，当根据年龄对264名空腹受试者的结果进行合并时，结果表明60岁以上人群血浆中的平均离子氟浓度（3.89 μmol/L）和总氟浓度（6.58 μmol/L）显著高于较年轻的年龄组。对于较年轻的年龄组，离子氟的平均值在2.74至3.05 μmol/L之间，总氟的平均值在4.74至5.58 μmol/L之间。21至30岁个体的结合氟浓度（1.89 μmol/L）低于年龄较大的组（平均值在2.42至2.68 μmol/L之间），但与较年轻个体（2.21 μmol/L）的结合氟浓度没有显著差异。我们注意到平均离子氟浓度有随年龄增加的趋势，但仅在60岁以上的人群中，该浓度显著高于前一个十年组。
