Dotson A D, Raimer S S, Pursley T V, Tschen J
Arch Dermatol. 1981 Jul;117(7):422-6.
A dystrophic bullous eruption that met all the criteria for epidermolysis bullosa acquisita (EBA) developed in a 19-year-old woman five years before the onset of clinical and serologic evidence of systemic lupus erythematosus (SLE). Electron microscopic studies of skin lesions both before and after the development of SLE were consistent with the previously reported electron microscopic findings in patients with EBA. Direct immunofluorescence microscopic studies done on bullae before and after the diagnosis of SLE showed linear depositions of immunoglobulin and complement; indirect immunofluorescence microscopic study findings consistently showed no abnormalities. These findings have been noted in other cases of EBA and may implicate autoimmune, immunologic factors in the pathogenesis of the disease process. To our knowledge, the finding of SLE in association with EBA has not been previously reported.
一名19岁女性在出现系统性红斑狼疮（SLE）临床及血清学证据的五年前，发生了一种符合获得性大疱性表皮松解症（EBA）所有标准的营养不良性大疱性皮疹。在SLE发生之前和之后对皮肤病变进行的电子显微镜研究，与先前报道的EBA患者的电子显微镜检查结果一致。在SLE诊断前后对水疱进行的直接免疫荧光显微镜研究显示免疫球蛋白和补体呈线性沉积；间接免疫荧光显微镜研究结果始终未显示异常。这些发现已在其他EBA病例中得到证实，可能暗示自身免疫、免疫因素在疾病过程的发病机制中起作用。据我们所知，SLE与EBA相关的发现此前尚未见报道。
