Valone J A, McMeel J W, Franks E P
Arch Ophthalmol. 1981 Aug;99(8):1362-6. doi: 10.1001/archopht.1981.03930020236003.
One hundred thirty-six patients with proliferative diabetic retinopathy (PDR) in one eye and nonproliferative diabetic retinopathy (NPDR) in the fellow eye on initial examination were followed up for at least three months. Eight percent of the eyes with NPDR were eliminated from further consideration by treatment within the first three months. Proliferative diabetic retinopathy developed in 58% of the remaining eyes with NPDR, usually within two years of the initial examination. Proliferative diabetic retinopathy developed in a significantly greater percentage of diabetics who were younger than 40 years than in diabetics older than 60 years. Poor visual prognosis among eyes that initially had NPDR was associated with advanced angiopathy or exudation on initial examination and also may have been associated with the subsequent development of PDR. Neither the development of PDR nor the final visual acuity in these eyes could be correlated with vascular disease outside the eye, the degree of PDR in the fellow eye, or the presence of higher intraocular pressure in the eye with NPDR on initial examination. Forty-one percent of the eyes with unilateral PDR were eliminated from consideration by prompt treatment. Most remaining eyes with PDR also showed progressive fundus pathologic conditions.
136例初诊时一眼患有增殖性糖尿病视网膜病变（PDR）而另一眼患有非增殖性糖尿病视网膜病变（NPDR）的患者接受了至少3个月的随访。在最初3个月内，8%患有NPDR的眼因接受治疗而不再纳入进一步研究。在其余患有NPDR的眼中，58%发展为增殖性糖尿病视网膜病变，通常是在初诊后的两年内。40岁以下的糖尿病患者中，发展为增殖性糖尿病视网膜病变的比例显著高于60岁以上的糖尿病患者。初诊时患有NPDR的眼中，较差的视力预后与初诊时的严重血管病变或渗出有关，也可能与随后PDR的发生有关。这些眼中PDR的发生及最终视力均与眼外血管疾病、对侧眼PDR的程度或初诊时患有NPDR的眼内较高眼压无关。41%的单侧PDR眼因及时治疗而不再纳入研究。大多数剩余的PDR眼也显示出眼底病变的进展。
