体内和体外腐蚀测试的考量因素

In vivo and in vitro considerations of corrosion testing.

作者信息

Brown S A, Merritt K

出版信息

Biomater Med Devices Artif Organs. 1981;9(1):57-63. doi: 10.3109/10731198109117601.

DOI:10.3109/10731198109117601

Abstract

In vitro experiments were conducted in which the fretting corrosion rate of stainless steel plates and screws in 0.9% saline was compared with the rate in solutions of 10% calf serum in saline. The results demonstrated a ten-fold decrease in the fretting corrosion rate with the addition of serum to saline. However, it also demonstrated that the lower concentration of nickel in the serum solutions was more biologically active than the higher concentration in saline when the solutions were used to skin test rabbits made allergic to nickel by injection.

摘要

进行了体外实验，比较不锈钢板和螺钉在0.9%盐水中的微动腐蚀速率与在含10%小牛血清的盐溶液中的速率。结果表明，向盐水中添加血清后，微动腐蚀速率降低了十倍。然而，实验还表明，当将这些溶液用于对通过注射镍而过敏的兔子进行皮肤试验时，血清溶液中较低浓度的镍比较高浓度的盐水具有更高的生物活性。