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关于坦克状运动的人体红细胞中的能量耗散

On the energy dissipation in a tank-treading human red blood cell.

作者信息

Fischer T M

出版信息

Biophys J. 1980 Nov;32(2):863-8. doi: 10.1016/S0006-3495(80)85022-3.

DOI:10.1016/S0006-3495(80)85022-3
PMID:7260306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1327244/
Abstract

The energy dissipation in the membrane (ED mem) and in the cytoplasm (ED cyt) of tank-treading human red blood cells is estimated. The tank-tread motion of the membrane occurs when the cells in a sheared suspension assume a steady-state of orientation (Fischer et al., 1978, Science [Wash. D. C.], 202:894). The kinematic data used are from red cells suspended either in a dextran-saline solution at a low hematocrit, or in plasma at a hematocrit of 45%. The viscosities of the cytoplasm and the membrane are taken from the literature. The cell in dextran was subjected to seven different shear rates. Both ED mem and ED cyt showed a strong increase with shear rate. Their ratio, however, was always of the order of 1. From this value and the value which was given by Hochmuth et al. (1979, Biophys. J., 26:101) for a shape recovery of a red cell, it is concluded that the range of ED mem/ED cyt for all possible geometries is 1-100.

摘要

估算了人红细胞“坦克履带”运动时细胞膜(EDmem)和细胞质(EDcyt)中的能量耗散。当处于剪切悬浮液中的细胞达到稳定取向状态时,细胞膜会发生“坦克履带”运动(Fischer等人,1978年,《科学》[华盛顿特区],202:894)。所使用的运动学数据来自悬浮于低血细胞比容的葡聚糖 - 盐溶液中或血细胞比容为45%的血浆中的红细胞。细胞质和细胞膜的粘度取自文献。处于葡聚糖中的细胞经受了七种不同的剪切速率。EDmem和EDcyt均随剪切速率大幅增加。然而,它们的比值始终约为1。根据该值以及Hochmuth等人(1979年,《生物物理学杂志》,26:101)给出的红细胞形状恢复值,得出所有可能几何形状下EDmem/EDcyt的范围为1 - 100。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f7/1327244/65f1367127c4/biophysj00251-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f7/1327244/65f1367127c4/biophysj00251-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f7/1327244/65f1367127c4/biophysj00251-0188-a.jpg

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