Tillmann W, Merten A, Lakomek M, Gahr M, Fiechtl J, Schröter W
Blut. 1981 Aug;43(2):125-8. doi: 10.1007/BF00320473.
The rheological properties of erythrocytes of 47 diabetic children and adolescents were studied. Deformability of red cells of 32 patients under "poor" metabolic control was markedly decreased while the deformability of red cells of patients (15 individuals) under "good" control was normal. This diminished flexibility of erythrocytes of patients under "poor" control can be explained partly by an increased concentration of free fatty acids in plasma. Moreover we found a decreased fluidity of the intracellular hemoglobin caused possibly by a decreased concentration of 2, 3-diphosphoglycerate in the cells.
对47名糖尿病儿童和青少年的红细胞流变学特性进行了研究。32名代谢控制“差”的患者红细胞变形性明显降低，而代谢控制“良好”的患者（15人）红细胞变形性正常。代谢控制“差”的患者红细胞柔韧性降低，部分原因可能是血浆中游离脂肪酸浓度升高。此外，我们发现细胞内血红蛋白的流动性降低，可能是由于细胞内2,3-二磷酸甘油酸浓度降低所致。
