Fuglsang H, Anderson J
Tropenmed Parasitol. 1978 Sep;29(3):335-8.
Nifurtimox tablets were given at a dose of 15-20 mg per kg bodyweight daily for 5 days to 14 patients with onchocerciasis in the savanna of Cameroon. In general the therapy was well tolerated. During the course there were no clinical signs of microfilaricidal effects. 6 patients were re-examined after an interval of 8 months. The microfilarial load had decreased in 3 patients, while it was unchanged in 2, and increased in the last. There was no improvement in ocular lesions. These preliminary results suggest a possible effect on the adult parasite, and further trials are justified.
硝呋替莫片以每日每公斤体重15 - 20毫克的剂量，连续5天给予喀麦隆稀树草原地区的14名盘尾丝虫病患者。总体而言，该疗法耐受性良好。在治疗过程中，未出现杀微丝蚴作用的临床体征。8个月后对6名患者进行了复查。3名患者的微丝蚴负荷有所下降，2名患者的微丝蚴负荷未变，最后1名患者的微丝蚴负荷增加。眼部病变未见改善。这些初步结果表明对成虫可能有作用，进一步试验是合理的。
