不同的下丘脑受体介导5-羟色胺和色胺引起的大鼠核心体温变化。
Different hypothalamic receptors mediate 5-hydroxytryptamine- and tryptamine-induced core temperature changes in the rat.
作者信息
Cox B, Lee T F, Martin D
出版信息
Br J Pharmacol. 1981 Mar;72(3):477-82. doi: 10.1111/j.1476-5381.1981.tb10999.x.
Abstract
1 Unilateral intrahypothalamic injection of 5-hydroxytryptamine (5-HT) caused a dose-related fall in core temperature in rats, whereas injection of tryptamine into the same site caused a dose-related rise in core temperature. 2 The core temperature changes induced by 5-HT or tryptamine were inhibited by intrahypothalamic pretreatment with indoleamine receptor antagonists in a dose-related manner. 3 Other neurotransmitter antagonists, haloperidol, atropine, phentolamine and (-)-propranolol, had no significant effect on core temperature changes induced by 5-HT or tryptamine. 4 A differential antagonism was observed for the indoleamine receptor antagonists against 5-HT and tryptamine-induced core temperature changes. Methergoline and triflupromazine were more selective against tryptamine-induced hyperthermia, while cyproheptadine was more selective against 5-HT-induced hypothermia. 5 Intrahypothalamic pretreatment with 5,-7-dihydroxytryptamine (5,7-DHT) 42 nmol in 2 microliter inhibited tryptamine-induced hyperthermia, but was without effect on 5-HT-induced hypothermia. 6 These results suggest the possible existence of two different receptor populations within the preoptic anterior hypothalamus in rats; one specific for 5-HT and the other for tryptamine.
摘要
- 向大鼠下丘脑单侧注射5-羟色胺（5-HT）会导致核心体温呈剂量依赖性下降，而向同一部位注射色胺则会导致核心体温呈剂量依赖性上升。2. 5-HT或色胺诱导的核心体温变化会被下丘脑内预先用吲哚胺受体拮抗剂以剂量依赖性方式抑制。3. 其他神经递质拮抗剂，如氟哌啶醇、阿托品、酚妥拉明和（-）-普萘洛尔，对5-HT或色胺诱导的核心体温变化没有显著影响。4. 观察到吲哚胺受体拮抗剂对5-HT和色胺诱导的核心体温变化具有差异性拮抗作用。麦角新碱和三氟拉嗪对色胺诱导的体温过高更具选择性，而赛庚啶对5-HT诱导的体温过低更具选择性。5. 下丘脑内预先用2微升含42纳摩尔的5,7-二羟色胺（5,7-DHT）处理可抑制色胺诱导的体温过高，但对5-HT诱导的体温过低没有影响。6. 这些结果表明，大鼠视前区下丘脑前部可能存在两种不同的受体群体；一种对5-HT具有特异性，另一种对色胺具有特异性。
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本文引用的文献
1
A dopamine-5-hydroxytryptamine link in the hypothalamic pathways which mediate heat loss in the rat.大鼠下丘脑介导散热的神经通路中多巴胺与5-羟色胺的联系。
J Physiol. 1980 Jun;303:9-21. doi: 10.1113/jphysiol.1980.sp013266.
2
Receptors involved in the action of 5-HT and tryptamine on the isolated rat stomach fundus preparation.5-羟色胺和色胺对离体大鼠胃底制备物作用中涉及的受体。
Eur J Pharmacol. 1974 May;26(2):220-30. doi: 10.1016/0014-2999(74)90231-3.
3
Comparative studies of brain 5-hydroxytryptamine and tryptamine.大脑5-羟色胺与色胺的比较研究。
Adv Biochem Psychopharmacol. 1974;11(0):109-14.
4
Indoleamine antagonists: relative potencies as inhibitors of tryptamine- and 5-hydroxytryptophan-evoked responses.吲哚胺拮抗剂：作为色胺和5-羟色氨酸诱发反应抑制剂的相对效力。
Br J Pharmacol. 1974 Feb;50(2):311-3. doi: 10.1111/j.1476-5381.1974.tb08577.x.
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7
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