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5-羟色胺诱导大鼠体温过低作为5-羟色胺受体定量研究的体内模型。

5-Hydroxytryptamine-induced hypothermia in rats as an in vivo model for the quantitative study of 5-hydroxytryptamine receptors.

作者信息

Cox B, Lee T F

出版信息

J Pharmacol Methods. 1981 Jan;5(1):43-51. doi: 10.1016/0160-5402(81)90101-7.

DOI:10.1016/0160-5402(81)90101-7
PMID:6115102
Abstract

Intrahypothalamic injection of 5-hydroxytryptamine (5-HT) caused a fall in core temperature in lightly restrained rats maintained at an ambient temperature of 17 degrees C. The hypothermia was blocked by 5-HT antagonists with a relative potency of methiothepin greater than methergoline greater than methysergide greater than cinanserin greater than cyproheptadine. The peripheral 5-HT antagonist, xylamidine, was not an antagonist, suggesting the hypothermia was of central origin. Other neurotransmitter antagonists, haloperidol, atropine, phentolamine, and propranolol failed to prevent 5-HT-induced hypothermia. This suggests that the hypothermic response to 5-HT can be used for a quantitative study of drug action at central 5-HT receptors.

摘要

在环境温度为17摄氏度的轻度束缚大鼠中，下丘脑内注射5-羟色胺（5-HT）会导致核心体温下降。5-HT拮抗剂可阻断这种体温过低现象，其相对效力为：甲硫噻嗪大于麦角新碱大于甲基麦角新碱大于辛那色林大于赛庚啶。外周5-HT拮抗剂二甲苯胺不是拮抗剂，这表明体温过低是中枢性的。其他神经递质拮抗剂，如氟哌啶醇、阿托品、酚妥拉明和普萘洛尔未能预防5-HT诱导的体温过低。这表明对5-HT的体温过低反应可用于对中枢5-HT受体处药物作用的定量研究。

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5-Hydroxytryptamine-induced hypothermia in rats as an in vivo model for the quantitative study of 5-hydroxytryptamine receptors.5-羟色胺诱导大鼠体温过低作为5-羟色胺受体定量研究的体内模型。
J Pharmacol Methods. 1981 Jan;5(1):43-51. doi: 10.1016/0160-5402(81)90101-7.
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Chronic lithium treatment enhances the postsynaptic 5-HT1A receptor-mediated 5-HT behavioral syndrome induced by 8-OH-DPAT in rats via catecholaminergic systems.
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