Weinberg U
Brain Res. 1981 Jul 27;217(1):221-4. doi: 10.1016/0006-8993(81)90205-5.
Melatonin, an anti-gonadotropic pineal hormone, is known to have a very short half-life in the adult animal. The objective of the present study was to determine whether the fate of melatonin in the neonate is different from that of the adult rat. Groups of 5-day-old rats were injected intraperitoneally with [3H]melatonin. The animals were killed at 10, 60 and 90 min intervals following the injections and the livers and brains immediately removed and homogenized. A high pressure liquid chromatographic analysis of the liver and brain extracts revealed that in sharp contrast to the rapid disappearance of melatonin in the adult, melatonin disappearance in the neonate is greatly decreased.
褪黑素是一种抗促性腺的松果体激素，已知其在成年动物体内的半衰期非常短。本研究的目的是确定褪黑素在新生儿体内的代谢情况是否与成年大鼠不同。给5日龄大鼠腹腔注射[3H]褪黑素。注射后每隔10、60和90分钟处死动物，并立即取出肝脏和大脑进行匀浆。对肝脏和大脑提取物进行的高压液相色谱分析显示，与成年动物体内褪黑素的快速消失形成鲜明对比的是，新生儿体内褪黑素的消失大大减少。
