Weinberg U, Gasparini F J, Weitzman E D
Endocrinology. 1981 Mar;108(3):1081-2. doi: 10.1210/endo-108-3-1081.
The developmental pattern of the in vitro rat liver melatonin degrading activity was studied. Livers from rats 3, 12, 16, 21, 30 and 90 days old were incubated with [3H] melatonin. A high pressure liquid chromatography (HPLC) technique was used to determine the appearance of melatonin metabolic product--6-hydroxymelatonin--in the liver extract. Catabolic activity belong very low at age 3 days, increased rapidly with age and reached maximum activity between the ages 21 to 30 days.
研究了体外大鼠肝脏褪黑素降解活性的发育模式。将3日龄、12日龄、16日龄、21日龄、30日龄和90日龄大鼠的肝脏与[3H]褪黑素一起孵育。采用高压液相色谱（HPLC）技术测定肝脏提取物中褪黑素代谢产物——6-羟基褪黑素的出现情况。分解代谢活性在3日龄时非常低，随年龄迅速增加，并在21至30日龄之间达到最大活性。
