急性呼吸道病毒感染期间茶碱药代动力学发生改变。
Altered theophylline pharmacokinetics during acute respiratory viral illness.
作者信息
Chang K C, Bell T D, Lauer B A, Chai H
出版信息
Lancet. 1978 May 27;1(8074):1132-3. doi: 10.1016/s0140-6736(78)90305-7.
Abstract
The plasma half-life of theophylline was determined during and 1 month after serologically confirmed upper-respiratory-tract viral illness in six children with chronic asthma. In this group the plasma-theophylline half-life (mean = 419.8 min) was significantly longer during the acute stage of their illness than 1 month later (mean 249.9 min). There was no appreciable change in half-life in 4 patients who were febrile but in whom seroconversion did not occur. These preliminary results suggest that certain upper-respiratory-tract viral infections may affect theophylline metabolism.
摘要
在6名患有慢性哮喘的儿童中，测定了血清学确诊的上呼吸道病毒感染期间及感染后1个月时茶碱的血浆半衰期。在这组患儿中，疾病急性期的血浆茶碱半衰期（平均 = 419.8分钟）显著长于1个月后（平均249.9分钟）。4名发热但未发生血清转化的患儿的半衰期没有明显变化。这些初步结果表明，某些上呼吸道病毒感染可能会影响茶碱的代谢。
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本文引用的文献
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An ultraviolet spectrophotometric method for the determination of theophylline and theobromine in blood and tissues.一种用于测定血液和组织中茶碱和可可碱的紫外分光光度法。
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Variation in theophylline clearance rate with time in chronic childhood asthma.儿童慢性哮喘患者中茶碱清除率随时间的变化
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