Stepan'ian L I, Vakhtin Iu B
Tsitologiia. 1978 Sep;20(9):1100-3.
The selection of tumor cells for their affinity to pulmonary tissue significantly enhances their ability to invade and proliferate. The intraveneous inoculation of these cells into mice increases the number of animals bearing tumour clones and the number of clones per animal. The adduction of unfixed macrophages by means of intramuscular injection of BGG, which is known to increase the implanted tumour growth, did not increase either the percentage of animals bearing tumor cell clones or the number of clones per a lung, in our experiments. The affinity of tumor cells to pulmonary tissue obviously does not depend significantly on the interaction with unfixed macrophages. We assume that the selection of tumor cells for their affinity to pulmonary tissue is not necessarily connected with changes in their antigenous properties for recipient animals.
选择对肺组织具有亲和力的肿瘤细胞可显著增强其侵袭和增殖能力。将这些细胞静脉注射到小鼠体内会增加携带肿瘤克隆的动物数量以及每只动物体内的克隆数量。在我们的实验中，通过肌肉注射已知可促进植入肿瘤生长的卡介苗（BGG）来引入未固定的巨噬细胞，并未增加携带肿瘤细胞克隆的动物百分比或每只肺中的克隆数量。肿瘤细胞对肺组织的亲和力显然并不显著依赖于与未固定巨噬细胞的相互作用。我们认为，选择对肺组织具有亲和力的肿瘤细胞不一定与它们对受体动物抗原特性的改变有关。
