Coulombe L, Rosser W W
Can Med Assoc J. 1981 Jul 1;125(1):37-40.
The immunity to rubella of 115 girls aged 10 to 14 years was tested in 1978. The proportion of girls found to be immune was 80%, similar to rates in the prevaccination era. Nearly half of the immunity was from documented vaccination, and the other half was presumably from infection with wild rubella virus. The vaccination failure rate was 12%. Because of declining immunity to rubella of women of child-bearing age, detecting low levels of immunity in these women is becoming increasingly important. Immunization of 12- to 15-month-old children has not been effective. Vaccinating all girls 10 to 12 years old would likely be the most effective method of preventing an increase in the incidence of congenital rubella syndrome in the next decade.
1978年对115名年龄在10至14岁的女孩进行了风疹免疫力检测。发现具有免疫力的女孩比例为80%，与疫苗接种前时代的比例相似。近一半的免疫力来自有记录的疫苗接种，另一半可能来自野生风疹病毒感染。疫苗接种失败率为12%。由于育龄妇女对风疹的免疫力下降，检测这些妇女中的低水平免疫力变得越来越重要。对12至15个月大的儿童进行免疫接种并不有效。对所有10至12岁的女孩进行疫苗接种可能是预防未来十年先天性风疹综合征发病率上升的最有效方法。
