Buchwald H, Grage T B, Vassilopoulos P P, Rohde T D, Varco R L, Blackshear P J
Cancer. 1980 Mar 1;45(5):866-9. doi: 10.1002/1097-0142(19800301)45:5<866::aid-cncr2820450507>3.0.co;2-3.
Intraarterial infusion chemotherapy has several theoretical advantage over conventional therapy for the treatment of unresectable malignancies. However, the catheter problems and patient restriction to the hospital associated with its use have resulted in infrequent application and a notable lack of progress in this field of oncology. This paper describes the use of a totally implantable, percutaneously refillable infusion pump in 5 patients with primary or metastatic carcinoma of the liver. The infusion cannulae were placed into the hepatic arteries under direct vision at laparotomy, and the pumps were placed in subcutaneous pockets. Four patients received infusions of 5-fluorodeoxyuridine at rates of 0.2-0.5 mg/kg/day for periods of three to 29 weeks; the pump in the fifth patient was defective and was removed. The implanted pumps were well tolerated in these subjects, who received chemotherapy as outpatients; the only adverse effects noted were related to FUDR toxicity. This implantable infusion pump appears to be a practical means of delivering long-term intraarterial infusion chemotherapy to outpatients.
对于不可切除的恶性肿瘤的治疗，动脉内灌注化疗相对于传统疗法具有若干理论优势。然而，与该疗法使用相关的导管问题以及患者需住院的限制，导致其应用并不频繁，且肿瘤学这一领域明显缺乏进展。本文描述了5例原发性或转移性肝癌患者使用完全植入式、经皮可再填充输液泵的情况。在剖腹手术直视下将输注套管置于肝动脉内，并将泵置于皮下袋中。4例患者以0.2 - 0.5mg/kg/天的速率输注5-氟脱氧尿苷，持续三至29周；第五例患者的泵有缺陷，已被取出。这些作为门诊患者接受化疗的受试者对植入的泵耐受性良好；唯一观察到的不良反应与氟尿苷毒性有关。这种可植入输液泵似乎是一种向门诊患者提供长期动脉内灌注化疗的实用手段。
