Green S B, Byar D P, Lamberg S I
Cancer. 1981 Jun 1;47(11):2671-7. doi: 10.1002/1097-0142(19810601)47:11<2671::aid-cncr2820471125>3.0.co;2-x.
The prognostic importance of various factors was analyzed for 347 patients registered by the Mycosis Fungoides Cooperative Group (MFCG). Extent of skin involvement at the time of registration and number of sites of clinically enlarged lymph nodes were clearly the most important prognostic variables, and were combined into a single variable, TN stage, for adjusted analyses of other factors. Sex, history of tonsillectomy, immunoglobulin E, and telangiectasia did not significantly affect survival. The effects of race and allergic history were questionable and need further study. Age, pruritus, burning, alopecia, ulcers, and erosion were important when studied alone, but their effects were no longer statistically significant after adjustment for TN stage. Chills and malaise, the latter a symptom of debility, retained prognostic significance after such adjustment. This analysis demonstrates the importance of considering the joint effects of multiple prognostic factors rather than analyzing them one at a time.
对蕈样肉芽肿协作组（MFCG）登记的347例患者分析了各种因素的预后重要性。登记时皮肤受累范围和临床肿大淋巴结部位数量显然是最重要的预后变量，并将其合并为一个变量TN分期，用于对其他因素进行校正分析。性别、扁桃体切除史、免疫球蛋白E和毛细血管扩张对生存率无显著影响。种族和过敏史的影响存在疑问，需要进一步研究。单独研究时，年龄、瘙痒、烧灼感、脱发、溃疡和糜烂很重要，但在对TN分期进行校正后，它们的影响不再具有统计学意义。寒战和不适（后者是虚弱的症状）在进行此类校正后仍保留预后意义。该分析表明，考虑多个预后因素的联合作用而非逐一分析这些因素非常重要。
