Berry P L, McEnery P T, McAdams A J, West C D
Clin Nephrol. 1981 Aug;16(2):101-6.
In one sibship, a brother had membranoproliferative glomerulonephritis (MPGN) Type III and a sister, Type I. In both children, clinical and laboratory manifestations were typical. In another sibship, both boys had Type I MPGN by glomerular morphology but over a 4 year period of follow-up, neither had hematuria or hypocomplementemia, both common manifestations of this type. Several other reports give suggestive evidence of MPGN in siblings but details are scanty. The familial nature of the disease adds to the earlier observation of its predilection for the white race to strengthen the concept that genetic factors are involved in its origin.
在一个家庭中，一个兄弟患有III型膜增生性肾小球肾炎（MPGN），而他的妹妹患有I型。这两个孩子的临床和实验室表现都很典型。在另一个家庭中，两个男孩通过肾小球形态学诊断为I型MPGN，但在4年的随访期间，两人都没有血尿或低补体血症，而这两种情况是该类型的常见表现。其他几份报告也提供了兄弟姐妹中存在MPGN的暗示性证据，但细节很少。该疾病的家族性特征，再加上之前观察到的其对白人种族的偏好，进一步强化了遗传因素参与其发病的概念。
