Marecková O, Skála I, Tomková D, Schück O, Nádvorníková H, Doberský P
Czech Med. 1981;4(1-2):81-90.
When following the spectrum of plasmatic amino acids in patients with chronic renal failure in course of a six-week treatment with low-protein diets, an increase of non-essential amino acids, glycine and alanine, was observed in the case of a diet containing 20 g of proteins. A further decrease of tyrosine and threonine, which were decreased already before the therapy, suggests the presence of an effect of the reduced intake of proteins on the levels of these amino acids. High levels of methionine occurring in the case of the diet containing 20 g of proteins a day, supplemented by methionine to a minimally necessary requirement according to Rose, show different requirements) for this amino acid in patients with the chronic renal failure. A significant drop of the histidine and arginine as compared to the values before the treatment demonstrated that it is also necessary to take into account these amino acids when composing optimal amino acid formulation for uremics. A preliminary proposal is presented of a composition of amino acid mixture suitable for patients with chronic renal failure which differs essentially from the Rose formulation developed for a healthy organism. Different requirements for arginine are also considered in addition to the essential amino acids and histidine.
在对慢性肾衰竭患者采用低蛋白饮食进行为期六周的治疗过程中，跟踪其血浆氨基酸谱时发现，对于含20克蛋白质的饮食，非必需氨基酸、甘氨酸和丙氨酸有所增加。酪氨酸和苏氨酸在治疗前就已减少，进一步下降表明蛋白质摄入量减少对这些氨基酸水平产生了影响。对于每日含20克蛋白质且根据罗斯标准补充蛋氨酸至最低必需量的饮食，蛋氨酸水平较高，这表明慢性肾衰竭患者对该氨基酸有不同需求。与治疗前的值相比，组氨酸和精氨酸显著下降，这表明在为尿毒症患者配制最佳氨基酸配方时也必须考虑这些氨基酸。本文初步提出了一种适合慢性肾衰竭患者的氨基酸混合物组成方案，该方案与为健康机体开发的罗斯配方有本质区别。除了必需氨基酸和组氨酸外，还考虑了对精氨酸的不同需求。
