McAllister W A, Winfield C R, Collins J V
Eur J Clin Pharmacol. 1981;20(2):141-5. doi: 10.1007/BF00607151.
The pharmacokinetics of prednisolone have been studied in asthmatic patients following intravenous injection at three different doses and in normal volunteers at five oral doses. Plasma prednisolone concentrations were measured by radioimmunoassay. With increasing dose there is an increase in the apparent volume of distribution, plasma clearance and half life. The relationship between area under the plasma concentration time curve, maximum concentration and dose is linear but the regression lines do not pass through the origin. These findings following oral and intravenous administration confirm that prednisolone shows non-linear kinetics.
已对哮喘患者静脉注射三种不同剂量的泼尼松龙以及正常志愿者口服五种剂量的泼尼松龙后的药代动力学进行了研究。通过放射免疫分析法测定血浆泼尼松龙浓度。随着剂量增加，表观分布容积、血浆清除率和半衰期均增加。血浆浓度-时间曲线下面积、最大浓度与剂量之间的关系呈线性，但回归线不经过原点。口服和静脉给药后的这些发现证实泼尼松龙呈现非线性动力学。
