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双配体调节酶的指数模型。第1部分：根据初始速度数据确定模型常数的计算机程序。

Exponential model for a two-ligand, regulatory enzyme. Part 1: computer programs for the determination of the model constants from initial velocity data.

作者信息

Kinderlerer J, Ainsworth S, Gregory R B

出版信息

Int J Biomed Comput. 1981 Jul;12(4):291-313. doi: 10.1016/0020-7101(81)90042-8.

DOI:10.1016/0020-7101(81)90042-8
PMID:7263099
Abstract

The exponential model for a regulatory enzyme with two ligands (either two substrates or one substrate and an effector) provides an expression for the initial velocity of the catalysed reaction in terms of the fractional saturation of the enzyme by each ligand. This paper describes a program which determines the constants of the model from velocity data, measured with respect to the concentrations of the two ligands, when the corresponding fractional saturations are unknown. Listings of the essential routines, written in BASIC, are provided.

摘要

具有两种配体（两种底物或一种底物与一种效应物）的调节酶的指数模型，给出了根据每种配体使酶达到的分数饱和度来表示催化反应初速度的表达式。本文描述了一个程序，当相应的分数饱和度未知时，该程序可根据相对于两种配体浓度测得的速度数据来确定模型的常数。文中给出了用BASIC语言编写的基本程序清单。

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Exponential model for a two-ligand, regulatory enzyme. Part 1: computer programs for the determination of the model constants from initial velocity data.双配体调节酶的指数模型。第1部分：根据初始速度数据确定模型常数的计算机程序。
Int J Biomed Comput. 1981 Jul;12(4):291-313. doi: 10.1016/0020-7101(81)90042-8.
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引用本文的文献

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The regulatory properties of rabbit muscle pyruvate kinase. The influence of effector concentrations.兔肌丙酮酸激酶的调节特性。效应物浓度的影响。
Biochem J. 1983 Feb 1;209(2):413-5. doi: 10.1042/bj2090413.
2
The regulatory properties of rabbit muscle pyruvate kinase. The influence of substrate concentrations.兔肌丙酮酸激酶的调节特性。底物浓度的影响。
Biochem J. 1983 Feb 1;209(2):401-11. doi: 10.1042/bj2090401.
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The regulatory properties of yeast pyruvate kinase.酵母丙酮酸激酶的调节特性。
Biochem J. 1984 Feb 1;217(3):641-7. doi: 10.1042/bj2170641.
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Analysis of Hill slopes predicted by the four-ligand exponential model for a regulatory enzyme.对一种调节酶的四配体指数模型预测的山坡进行分析。
Biochem J. 1986 Mar 15;234(3):717-26. doi: 10.1042/bj2340717.