Col J, Wijns W, Brasseur L, Lesne M
Int J Clin Pharmacol Ther Toxicol. 1981 Jul;19(7):314-8.
Recent studies have demonstrated that the biovailability of gitoxin could be increased to 100%. Favorable pharmacokinetic parameters for this glycoside have also been found in humans. The present paper deals with the comparative hemodynamic effect of digoxin and gitoxin on nine patients suffering from heart failure. The study was conducted in a coronary care unit with continuous hemodynamic monitoring. After intravenous administration of 1 mg digoxin or gitoxin, only gitoxin was observed to have an inotropic effect leading to significant improvement of the low cardiac output in these patients.
最近的研究表明，地高辛毒苷的生物利用度可提高到100%。在人体中也发现了这种糖苷有利的药代动力学参数。本文探讨了地高辛和地高辛毒苷对9例心力衰竭患者的血流动力学比较效应。该研究在冠心病监护病房进行，并持续进行血流动力学监测。静脉注射1毫克地高辛或地高辛毒苷后，仅观察到地高辛毒苷具有正性肌力作用，可显著改善这些患者的低心输出量。
