Klein W W, Pavek P
Arzneimittelforschung. 1978;28(3a):553-5.
In 10 patients with arterial hypertension and left heart failure the hemodynamic effect of 14-hydroxy-3-beta-[4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (Ky 18, meproscillarin, Clift) was compared with placebo in a double-blind study. 15 min after oral administration of meproscillarin there was an increase of cardiac output and stroke volume by up to 25%. Heart rate, arterial blood pressure and left ventricular filling pressure remained unchanged.
在一项双盲研究中，对10例动脉高血压合并左心衰竭患者，比较了14-羟基-3-β-[4-O-甲基-α-L-鼠李吡喃糖基)氧基]-14β-蟾蜍-4,20,22-三烯内酯（Ky 18，美普罗西拉林，克利夫特）与安慰剂的血流动力学效应。口服美普罗西拉林15分钟后，心输出量和每搏输出量增加高达25%。心率、动脉血压和左心室充盈压保持不变。
