大鼠气管黏液的pH值

pH of mucus in rat trachea.

作者信息

Gatto L A

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun;50(6):1224-6. doi: 10.1152/jappl.1981.50.6.1224.

DOI:10.1152/jappl.1981.50.6.1224

Abstract

The pH of the mucous coat of the trachea was measured in vivo through a tracheal window in anesthetized rats. Readings ranged from 7.42 to 7.57 and averaged 7.52 +/- 0.05 (SD) pH units. Injections of pilocarpine (cholinomimetic) were followed by a statistically significant decrease in pH to 7.46 +/- 0.05 (SD) and a subsequent return to initial values. These readings are in the region of what is accepted as the gel point of mucus. This closeness to the inflection point between sol and gel was not reported before and may explain some of the in situ flow properties of mucus.

摘要

通过麻醉大鼠的气管窗口在体内测量气管黏液层的pH值。读数范围为7.42至7.57，平均为7.52±0.05（标准差）pH单位。注射毛果芸香碱（拟胆碱药）后，pH值在统计学上显著下降至7.46±0.05（标准差），随后又恢复到初始值。这些读数处于被认为是黏液凝胶点的范围内。此前未报道过与溶胶和凝胶之间拐点如此接近的情况，这可能解释了黏液在原位的一些流动特性。