Hunt C E, McCulloch K, Brouillette R T
J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun;50(6):1313-7. doi: 10.1152/jappl.1981.50.6.1313.
The ventilatory response to hypoxia and to hypercarbia was assessed in 36 near-miss sudden infant death syndrome (N.M SIDS) and 23 control infants. Base-line measurements during non-REM sleep documented no significant difference in respiratory frequency, alveolar CO2 and O2 partial pressure (PAco2 and PAo2) or tidal volume between the N-M SIDS and control infants. In the N.M SIDS group, mean inspiratory flow and minute ventilation (VI) were significantly lower than in the control group (p less than 0.001 and p less than 0.01, respectively), and the slope of the ventilatory response to hypercarbia ((delta VI/Torr Paco2) was only 21 +/- 1.9 (SE) ml.kg-1 min-1 Torr PAco2 compared with 62 +/- 3.5 in controls (p less than 0.001). For both groups, the increase in ventilation with hypoxia appeared linear within the PAo2 range assessed (65-115 Torr) and was therefore expressed as the slope of the delta VI/PAo2 plot (ml.kg-1 min-1 per Torr PAo2). The slope of the hypoxic ventilatory response was significantly less in the N-M SIDS than in the control group, -8.3 +/- 1.0 VS. -19.9 +/- 1.5, respectively (p less than 0.001). In summary, in comparison to control infants, N-M SIDS infants as a group have a significantly smaller increase in VI in response to hypoxia as well as to hypercarbia.
对36名接近猝死的婴儿（N.M SIDS）和23名对照婴儿进行了对低氧和高碳酸血症的通气反应评估。非快速眼动睡眠期间的基线测量结果显示，N.M SIDS婴儿和对照婴儿在呼吸频率、肺泡二氧化碳和氧气分压（PAco2和PAo2）或潮气量方面没有显著差异。在N.M SIDS组中，平均吸气流量和分钟通气量（VI）显著低于对照组（分别为p<0.001和p<0.01），对高碳酸血症的通气反应斜率（（delta VI/Torr Paco2）仅为21±1.9（SE）ml.kg-1 min-1 Torr PAco2，而对照组为62±3.5（p<0.001）。对于两组，在评估的PAo2范围内（65-115 Torr），低氧引起的通气增加呈线性，因此表示为delta VI/PAo2图的斜率（ml.kg-1 min-1 per Torr PAo2）。N.M SIDS组的低氧通气反应斜率显著低于对照组，分别为-8.3±1.0和-19.9±1.5（p<0.001）。总之，与对照婴儿相比，N.M SIDS婴儿作为一个群体，对低氧和高碳酸血症的反应中VI的增加明显较小。
