Lewis N C, McBride J T, Brooks J G
Department of Pediatrics, School of Medicine, University of Rochester, New York.
J Pediatr. 1988 Aug;113(2):307-11. doi: 10.1016/s0022-3476(88)80270-1.
We measured ventilatory responses to progressive isocapnic hypoxia and to hyperoxic hypercapnia (CO2) using rebreathing techniques in 16 parents of infants with autopsy-confirmed sudden infant death syndrome (SIDS) and 18 control parents matched for age, sex, and body size. Response to ventilatory loading was assessed by repeating the CO2 test with an inspiratory flow-resistive load (16 cm H2O/L/sec). During loaded and unloaded CO2 tests, respiratory effort was also assessed by measuring the pressure generated in the first 0.1 second (P0.1) of the subsequent inspiratory effort after brief manual occlusion of the inspiratory line. Ventilatory responses of the parents of victims of SIDS to chemical and mechanical stimulation were not significantly different from those of control parents. Responses in both groups were similar to previously reported normal values. There was a linear increase in ventilation (VE) in response to hypercapnia and hypoxia and in P0.1 in response to hypercapnia. We found expected increases in P0.1/PCO2 and decreases in VE/PCO2 slopes during loaded breathing in all subjects, but no difference between groups. We conclude that parents of SIDS victims have normal ventilatory chemosensitivity and respiratory drive.
我们采用重复呼吸技术，对16名经尸检确诊为婴儿猝死综合征（SIDS）的婴儿的父母以及18名年龄、性别和体型匹配的对照父母，测量了他们对渐进性等碳酸血症性低氧和高氧性高碳酸血症（CO₂）的通气反应。通过使用吸气流量阻力负荷（16 cm H₂O/L/秒）重复进行CO₂测试，评估对通气负荷的反应。在有负荷和无负荷的CO₂测试期间，还通过测量在短暂手动阻塞吸气管道后随后吸气努力的前0.1秒内产生的压力（P0.1）来评估呼吸努力。SIDS受害者的父母对化学和机械刺激的通气反应与对照父母没有显著差异。两组的反应与先前报告的正常值相似。对高碳酸血症和低氧的反应中，通气量（VE）呈线性增加，对高碳酸血症的反应中P0.1呈线性增加。我们发现所有受试者在有负荷呼吸期间，P0.1/PCO₂预期增加，VE/PCO₂斜率预期降低，但两组之间没有差异。我们得出结论，SIDS受害者的父母具有正常的通气化学敏感性和呼吸驱动力。
