Springer A D
J Comp Neurol. 1981 Jun 10;199(1):87-95. doi: 10.1002/cne.901990107.
Optic nerve regeneration was examined with [3H]proline radioautography in fish that had one nerve crushed. Fibers had not yet grown beyond the crush site at 2 days post-crush (PC) and were at the optic chiasm by 4-5 days PC. By 6 days PC the fibers had reinnervated the rostral pole of the contralateral tectum, the lateral geniculate nucleus and area pretectalis dorsalis and ventralis. Area preopticus, nucleus opticus dorsolateralis and nucleus opticus commissurae posterior were partially reinnervated by 8 days PC. At this time numerous abnormal targets were labeled, including nucleus rotundus, nucleus isthmi, cerebellum, pituitary gland and ipsilateral optic tectum. Optic fibers also entered the posterior, intertectal and horizontal commissures, as well as tractus rotundus, the tectocerebellar, tectobulbar and mesencephalocerebellar tracts. In addition, fibers with the contralateral optic tectum were not restricted to their usual laminae. They were distributed from the superficial edge of the tectum to the ventricle. At 32 days PC only the normal retinal projections were evident, and all of the anomalous projections had disappeared. The anomalous projections may have either retracted or degenerated or become undetectable with radioautography.
在一侧视神经被挤压的鱼中，用[3H]脯氨酸放射自显影术检测视神经再生情况。挤压后2天（PC），纤维尚未生长至挤压部位以外，而在挤压后4 - 5天到达视交叉。到挤压后6天，纤维已重新支配对侧顶盖的吻侧极、外侧膝状体核以及背侧和腹侧前顶盖区。到挤压后8天，视前区、背外侧视核和后连合视核部分被重新支配。此时，许多异常靶点被标记，包括圆核、峡核、小脑、垂体和同侧视顶盖。视神经纤维还进入后连合、顶盖间连合和水平连合，以及圆核束、顶盖小脑束、顶盖延髓束和中脑小脑束。此外，与对侧视顶盖相连的纤维并不局限于其通常的板层。它们从顶盖的浅表边缘分布到脑室。在挤压后32天，仅可见正常的视网膜投射，所有异常投射均消失。异常投射可能已经回缩、退化或用放射自显影术无法检测到。
