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口服负荷后尿中低分子量聚乙二醇400的消除,作为肠道通透性的一种测量方法。

Elimination of low molecular weight polyethylene glycol 400 in the urine following an oral load, as a measure of intestinal permeability.

作者信息

Blätzinger J G, Rommel K, Ecknauer R

出版信息

J Clin Chem Clin Biochem. 1981 May;19(5):265-6. doi: 10.1515/cclm.1981.19.5.265.

DOI:10.1515/cclm.1981.19.5.265
PMID:7264567
Abstract

After an oral load of 10 g polyethylene glycol, its concentration in the urine was measured by gas chromatography. The coefficient of variation of the imprecision between run was about 11%. The urinary excretion was 25% of the administered dose with a coefficient of variation of the interindividual variation 26% and the intraindividual variation between 13% and 29%.

摘要

口服10克聚乙二醇后,通过气相色谱法测定其在尿液中的浓度。各批次测定不精密度的变异系数约为11%。尿排泄量为给药剂量的25%,个体间变异的变异系数为26%,个体内变异在13%至29%之间。

相似文献

1
Elimination of low molecular weight polyethylene glycol 400 in the urine following an oral load, as a measure of intestinal permeability.口服负荷后尿中低分子量聚乙二醇400的消除,作为肠道通透性的一种测量方法。
J Clin Chem Clin Biochem. 1981 May;19(5):265-6. doi: 10.1515/cclm.1981.19.5.265.
2
Aging-associated increase in intestinal absorption of macromolecules.衰老相关的肠道对大分子吸收的增加。
Gerontology. 1985;31(3):133-7. doi: 10.1159/000212694.
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Urinary excretion of polyethylene glycol 3350 and sulfate after gut lavage with a polyethylene glycol electrolyte lavage solution.用聚乙二醇电解质灌洗液进行肠道灌洗后聚乙二醇3350和硫酸盐的尿排泄情况。
Gastroenterology. 1986 Jun;90(6):1914-8. doi: 10.1016/0016-5085(86)90261-1.
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Parallel determination of gut permeability in man with M(r) 400, M(r) 1500, M(r) 4000 and M(r) 10,000 polyethylene glycol.
Eur J Clin Chem Clin Biochem. 1994 Nov;32(11):813-20. doi: 10.1515/cclm.1994.32.11.813.
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PEG 400, a hydrophilic molecular probe for measuring intestinal permeability.聚乙二醇400(PEG 400),一种用于测量肠道通透性的亲水性分子探针。
Gastroenterology. 1990 Jan;98(1):39-46. doi: 10.1016/0016-5085(90)91288-h.
6
A new micromethod for the quantification of low molecular weight oligomers of polyethylene glycol.一种用于定量聚乙二醇低分子量低聚物的新微量方法。
Clin Chim Acta. 1983 Nov 15;134(3):245-54. doi: 10.1016/0009-8981(83)90364-9.
7
Absorption profiles for polyethylene glycols after regional jejunal perfusion and oral load in healthy humans.健康人体局部空肠灌注和口服负荷后聚乙二醇的吸收情况
Dig Dis Sci. 1997 Apr;42(4):853-7. doi: 10.1023/a:1018836803254.
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Gastrointestinal permeability to polyethylene glycol: an evaluation of urinary recovery of an oral load of polyethylene glycol as a parameter of intestinal permeability in man.
Eur J Clin Invest. 1989 Aug;19(4):412. doi: 10.1111/j.1365-2362.1989.tb00250.x.
9
Separation and quantitation of polyethylene glycols 400 and 3350 from human urine by high-performance liquid chromatography.采用高效液相色谱法从人尿液中分离并定量分析聚乙二醇400和聚乙二醇3350。
J Pharm Sci. 1992 Apr;81(4):350-2. doi: 10.1002/jps.2600810412.
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Altered intestinal permeability to low-molecular-weight polyethyleneglycols (PEG 400) in patients with Crohn's disease.克罗恩病患者对低分子量聚乙二醇(PEG 400)的肠道通透性改变。
Acta Chir Scand. 1983;149(3):323-7.

引用本文的文献

1
Small intestinal permeability to mannitol, lactulose, and polyethylene glycol 400 in celiac disease.乳糜泻患者小肠对甘露醇、乳果糖和聚乙二醇400的通透性
Dig Dis Sci. 1984 Sep;29(9):809-16. doi: 10.1007/BF01318423.
2
PEG-400 excretion in patients with Crohn's disease, their first-degree relatives, and healthy volunteers.克罗恩病患者、其一级亲属及健康志愿者体内聚乙二醇400的排泄情况。
Dig Dis Sci. 1992 May;37(5):705-8. doi: 10.1007/BF01296426.