Reynolds G P, Riederer P
J Neural Transm. 1981;51(1-2):107-11. doi: 10.1007/BF01664008.
The effect of lisuride, bromocriptine, CQ 32-084 and CU 32-085 on the specific binding of radiolabelled spiperone to homogenates of human putamen taken post-mortem has been investigated. In addition, the binding of 3H-lisuride to such preparations has been studied. Lisuride is found to inhibit spiperone binding to the dopamine receptor at very low concentrations and to bind to the beta-adrenergic receptor at somewhat higher levels. Lisuride binding to the dopamine receptor was found to be antagonist-like. A measure of the in vivo effect of lisuride was obtained from investigations of brain tissue taken from a patient treated with the drug before death.
研究了利苏瑞ide、溴隐亭、CQ 32 - 084和CU 32 - 085对死后获取的人壳核匀浆中放射性标记螺哌隆特异性结合的影响。此外，还研究了3H - 利苏瑞ide与此类制剂的结合情况。发现利苏瑞ide在极低浓度下就能抑制螺哌隆与多巴胺受体的结合，而在稍高浓度下能与β - 肾上腺素能受体结合。利苏瑞ide与多巴胺受体的结合表现出类似拮抗剂的作用。通过对一名生前接受过该药物治疗的患者脑组织进行研究，获得了利苏瑞ide体内效应的相关指标。
