Gardiner M, Nilsson B, Rehncrona S, Siesjö B K
J Neurochem. 1981 Apr;36(4):1500-5. doi: 10.1111/j.1471-4159.1981.tb00592.x.
The effects of mild, moderate, and severe hypoxia on cerebral cortical concentrations of free fatty acids (FFAs) were investigated in artificially ventilated rats under nitrous oxide anaesthesia. No change occurred during either mild (arterial PO2 35-40 mm Hg) or moderate (PO2 25-30 mm Hg) hypoxia. The effects of severe hypoxia (PO2 about 20 mm Hg) combined with hypotension (mean arterial blood pressure 80-85 mm Hg) varied with the EEG pattern and the tissue energy state. Thus, a major increase in total as well as in individual FFAs occurred first when EEG was severely depressed (almost isoelectric) and energy homeostasis disrupted. On a relative basis the greatest change occurred in free arachidonic acid. It is concluded tha hypoxia is associated with an increase in the concentrations of FFAs in brain tissue, provided that tissue oxygen deficiency is severe enough to cause tissue energy failure. However, an increase in FFAs does not invariably accompany minor reductions in the adenylate energy charge (EC) of the tissue.
在一氧化二氮麻醉下，对人工通气的大鼠研究了轻度、中度和重度缺氧对大脑皮质游离脂肪酸（FFA）浓度的影响。在轻度（动脉血氧分压35 - 40 mmHg）或中度（血氧分压25 - 30 mmHg）缺氧期间均未发生变化。重度缺氧（血氧分压约20 mmHg）合并低血压（平均动脉血压80 - 85 mmHg）的影响随脑电图模式和组织能量状态而变化。因此，当脑电图严重抑制（几乎等电位）且能量稳态被破坏时，总FFA以及单个FFA首先会大幅增加。相对而言，游离花生四烯酸的变化最大。得出的结论是，只要组织缺氧严重到足以导致组织能量衰竭，缺氧就与脑组织中FFA浓度的增加有关。然而，FFA的增加并不总是伴随着组织腺苷酸能量电荷（EC）的轻微降低。
