索拉鲁宾酮，一种从绒毛索拉木中提取的新型抗白血病醌类化合物。

Soularubinone, a new antileukemic quassionoid from Soulamea tomentosa.

作者信息

Van Tri M, Polonsky J, Merienne C, Sevenet T

出版信息

J Nat Prod. 1981 May-Jun;44(3):279-84. doi: 10.1021/np50015a007.

Abstract

The structure of soularubinone 3, a new antileukemic quassinoid isolated from the leaves of Soulamea tomentosa (Brongn, and Gris), has been established by spectral and chemical methods. It has been shown to be the C-15 beta-hydroxy-isovaleric ester of glaucarubolone. Soularubinone shows significant antineoplastic activity against mouse leukemia P-388 and inhibits cell transformation induced by Rous sarcoma virus. The known quassinoid chaparrinone I has also been isolated.

摘要

从绒毛索拉木（Brongn.和Gris）叶中分离出的一种新的抗白血病苦木素类化合物索拉鲁宾酮3的结构已通过光谱和化学方法确定。它已被证明是格劳卡鲁宾酮的C-15β-羟基异戊酸酯。索拉鲁宾酮对小鼠白血病P-388显示出显著的抗肿瘤活性，并抑制劳氏肉瘤病毒诱导的细胞转化。还分离出了已知的苦木素类化合物查帕里酮I。