Cabezudo J M, Vaquero J, Areitio E, Martinez R, de Sola R G, Bravo G
J Neurosurg. 1981 Sep;55(3):371-5. doi: 10.3171/jns.1981.55.3.0371.
The authors have conducted a retrospective statistical study in a series of 45 patients with craniopharyngiomas in order to assess the value of different therapeutic approaches. All the patients included in the study were placed in three groups according to their method of treatment: 1) total excision; 2) subtotal excision; and 3) surgery followed by a course of radiotherapy (RT). Symptomatic recurrence was used to define failure of treatment. Of the patients subjected to total excision, 30% experienced recurrence after a mean time of 2 years. Tumors recurred in 71% of those treated by subtotal excision, with a mean time of 2.6 years. Of patients receiving RT in addition to surgery, only 6% had recurrence, after a mean time of 1 year. The authors conclude that the elective treatment for craniopharyngiomas is controlled subtotal surgery plus RT. Total excision should be attempted only if there is a negligible danger of mortality.
作者对45例颅咽管瘤患者进行了一项回顾性统计研究，以评估不同治疗方法的价值。根据治疗方法，将纳入研究的所有患者分为三组：1）全切除；2）次全切除；3）手术加放疗疗程（RT）。以症状复发来定义治疗失败。接受全切除的患者中，30%在平均2年后出现复发。次全切除治疗的患者中有71%复发，平均复发时间为2.6年。除手术外还接受放疗的患者中，只有6%在平均1年后复发。作者得出结论，颅咽管瘤的选择性治疗是可控的次全手术加放疗。只有在死亡风险可忽略不计的情况下才应尝试全切除。
