Nakamoto Y, Takeeda T, Hirano E, Morimoto K, Morisaka K
J Pharmacobiodyn. 1981 Apr;4(4):262-8. doi: 10.1248/bpb1978.4.262.
The transport of cephalothin (CET) to the exudate was investigated in croton oil-induced inflammatory rats following the intramuscular administration of CET-aqueous solution, CEt-O/W emulsion, or CET-W/O emulsion. The lymphatic transport of CET was the highest following the administration of W/O emulsion. The exudate level of CET was in a decreasing order of W/O emulsion, O/W emulsion, and aqueous solution. In the rat whose blood vessels at femoral rectus, the site of administration, were ligated, the plasma level was decreased by the administration of aqueous solution, but not by W/O emulsion. The exudate level of CET was significantly higher in case of W/O emulsion. Possible mechanisms involved are discussed.
在巴豆油诱导的炎症大鼠中，通过肌肉注射头孢噻吩水溶液、头孢噻吩-油包水乳液或头孢噻吩-水包油乳液，研究了头孢噻吩（CET）向渗出液的转运。注射水包油乳液后，CET的淋巴转运最高。CET的渗出液水平按水包油乳液、油包水乳液和水溶液的顺序递减。在给药部位股直肌血管被结扎的大鼠中，注射水溶液会使血浆水平降低，但注射水包油乳液则不会。水包油乳液组的CET渗出液水平显著更高。文中讨论了可能涉及的机制。
