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Synthesis and pharmacology of 8-amino-3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-cis-6,11-dimethyl-2,6-methano-3-benzazocine and related compounds.

作者信息

Wentland M P, Albertson N F, Pierson A K

出版信息

J Med Chem. 1980 Jan;23(1):71-4. doi: 10.1021/jm00175a013.

DOI:10.1021/jm00175a013
PMID:7359514
Abstract

The little compound 1a has been prepared and was found to be a strong, orally active agonist with narcotic--antagonist properties. 1a was prepared by two independent routes: (1) nitration of volazocine and subsequent reduction and (b) a sequence involving dissolving metal reduction of cyclazocine methyl ether, followed by oximination and Semmler--Wolff rearrangement. Several analogues were prepared and tested.

摘要

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