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57钴-博来霉素作为原发性肝细胞癌的肿瘤扫描剂

57-cobalt-bleomycin as a tumor scanning agent in primary hepatocellular cancer.

作者信息

Kew M, Allen J, Levin J

出版信息

Eur J Nucl Med. 1976 Dec 30;1(4):247-50. doi: 10.1007/BF00252171.

DOI:10.1007/BF00252171
PMID:72667
Abstract

57Co-bleomycin and 99mTc-sulfur colloid scans were performed in 13 southern African black patients with primary hepatocellular cancer (PHC) and 3 patients with other space-occupying hepatic lesions. Selective concentration of 57Co-bleomycin in the defect or defects seen on the 99mTc-sulfur colloid scan occurred in only 4 of the 13 (31%) patients with PHC. In the remaining PHC patients, as well as in the 2 patients with metastatic liver disease and the 1 patient with an amebic liver abscess, the 57 Co-bleomycin and 99mTc-sulfur colloid scans were identical. 57Co-bleomycin appears to have only a limited place as a tumor-seeking agent in the diagnosis of PHC in southern African blacks.

摘要

对13例南非黑人原发性肝细胞癌(PHC)患者和3例其他肝脏占位性病变患者进行了57钴-博来霉素和99m锝-硫胶体扫描。在13例PHC患者中,只有4例(31%)在99m锝-硫胶体扫描所见的缺损部位出现了57钴-博来霉素的选择性浓聚。在其余的PHC患者以及2例转移性肝病患者和1例阿米巴肝脓肿患者中,57钴-博来霉素和99m锝-硫胶体扫描结果相同。在南非黑人PHC的诊断中,57钴-博来霉素作为一种肿瘤寻踪剂似乎只有有限的应用价值。

相似文献

1
57-cobalt-bleomycin as a tumor scanning agent in primary hepatocellular cancer.57钴-博来霉素作为原发性肝细胞癌的肿瘤扫描剂
Eur J Nucl Med. 1976 Dec 30;1(4):247-50. doi: 10.1007/BF00252171.
2
Differentiating hepatic abscess from tumor: combined 111In white blood cell and 99mTc liver scans.肝脓肿与肿瘤的鉴别:铟-111标记白细胞与锝-99m肝脏扫描联合应用
AJR Am J Roentgenol. 1980 Jul;135(1):53-6. doi: 10.2214/ajr.135.1.53.
3
[Diagnosis of liver metastases with a combination of 57Co-bleomycin and 99mTc-sulfur colloid].[利用⁵⁷Co-博来霉素与⁹⁹ᵐTc-硫胶体联合诊断肝转移瘤]
Strahlentherapie Sonderb. 1975;74:490-5.
4
Scintigraphic diagnosis of primary hepatocellular carcinoma in the woodchuck (Marmota monax).土拨鼠(Marmota monax)原发性肝细胞癌的闪烁扫描诊断
Am J Vet Res. 1986 Mar;47(3):573-6.
5
[Study of space-occupying lesions in the liver using technetium-99m tin colloid and indium-113m chloride].[利用锝-99m 锡胶体和铟-113m 氯化物对肝脏占位性病变的研究]
S Afr Med J. 1985 Jan 26;67(4):121-4.
6
Diagnosis of hepatoma by scintigraphy using multiple radionuclides.使用多种放射性核素通过闪烁扫描法诊断肝癌。
J Surg Oncol. 1980;15(2):133-8. doi: 10.1002/jso.2930150205.
7
Hepatoma visualization with Tc-99m pyridoxylidene glutamate.用锝-99m 吡哆醛谷氨酸进行肝癌显像。
J Nucl Med. 1980 Aug;21(8):747-9.
8
Clinical evaluation of radio-labelled bleomycin for tumor detection.放射性标记博来霉素用于肿瘤检测的临床评估。
Nuklearmedizin. 1978 Dec;17(6):238-48.
9
[Distribution study using 57Co-, 51Cr-, 111In- and 99mTc-bleomycin in mice with a solid Ehrlich carcinoma].[使用57钴、51铬、111铟和99锝标记博来霉素在荷艾氏实体癌小鼠中的分布研究]
Nuklearmedizin. 1976 Aug;15(4):176-82.
10
[Scanning with bleomycin-57Co and microspheres of albumin-99mTc in the diagnosis of pulmonary thickening (author's transl)].
Radiol Med. 1978 May;64(5):575-83.

本文引用的文献

1
Cancer incidence in the Bantu and "Cape Colored" races of South Africa: report of a cancer survey in the Transvaal (1953-55).南非班图族和“开普有色人种”的癌症发病率:德兰士瓦癌症调查(1953 - 1955年)报告
J Natl Cancer Inst. 1960 Mar;24:589-671. doi: 10.1093/jnci/24.3.589.
2
On the mechanism of action of bleomycin. Strand scission of DNA caused by bleomycin and its binding to DNA in vitro.关于博来霉素的作用机制。博来霉素导致的DNA链断裂及其在体外与DNA的结合。
J Antibiot (Tokyo). 1970 Oct;23(10):473-80.
3
False-negative 75Se-selenomethionine scans in primary liver cancer.
原发性肝癌中75硒-硒代蛋氨酸扫描的假阴性结果
J Nucl Med. 1974 Apr;15(4):234-6.
4
Clinical evaluation of tumor scanning with 57Co-bleomycin.用57钴-博来霉素进行肿瘤扫描的临床评估。
Radiology. 1974 Oct;113(1):139-43. doi: 10.1148/113.1.139.
5
Clinical evaluation of radiolabeled bleomycin (BLEO) for tumor detection.放射性标记博来霉素(BLEO)用于肿瘤检测的临床评估。
J Nucl Med. 1974 Jun;15(6):386-90.
6
Some experience with 57Co-labeled bleomycin as a tumor-seeking agent.关于57钴标记博来霉素作为肿瘤定位剂的一些经验。
J Nucl Med. 1975 Nov;16(11):1058-69.
7
Chemical and biologic properties of isolated radiolabeled bleomycin preparations.分离出的放射性标记博来霉素制剂的化学和生物学特性。
J Nucl Med. 1975 Nov;16(11):1033-7.
8
Gallium-67-citrate scanning in primary cancer of the liver: diagnostic value in the presence of cirrhosis and relation to alpha-fetoprotein.枸橼酸镓-67扫描在原发性肝癌中的应用:在肝硬化存在情况下的诊断价值及与甲胎蛋白的关系
J Nucl Med. 1975 Oct;16(10):949-51.
9
Cobalt-labeled bleomycin--a new radiopharmaceutical for tumor localization. A comparative clinical evaluation with gallium citrate.钴标记博来霉素——一种用于肿瘤定位的新型放射性药物。与枸橼酸镓的比较临床评估。
J Nucl Med. 1975 Sep;16(9):839-41.