Cooper R L, McNamara M C, Thompson W G
Neurobiol Aging. 1980 Summer;1(1):53-7. doi: 10.1016/0197-4580(80)90024-x.
The effect of lysine vasopressin on the performance of young-adult and old rats subjected to a conditioned flavor aversion procedure was studied. Young rats maintained an aversion to a 0.1% saccharin solution significantly longer than did older rats. Treatment with lysine vasopressin ( 1 microgram/kg) during the recovery period prolonged the aversion in both age groups. A single injection of lysine vasopressin prior to the aversion procedure significantly reduced the age difference in extinction. These observations support the hypothesis that age-dependent changes in endogenous vasopressin synthesis or secretion underlie some of the behavioral deficits observed in old animals.
研究了赖氨酸加压素对接受条件性味觉厌恶程序的年轻成年大鼠和老年大鼠行为表现的影响。与老年大鼠相比，年轻大鼠对0.1%糖精溶液的厌恶持续时间明显更长。在恢复期用赖氨酸加压素（1微克/千克）治疗可延长两个年龄组的厌恶时间。在厌恶程序之前单次注射赖氨酸加压素可显著减少消退过程中的年龄差异。这些观察结果支持以下假设：内源性加压素合成或分泌的年龄依赖性变化是老年动物中观察到的一些行为缺陷的基础。
