Gremo F, Vernadakis A
Neurochem Res. 1981 Apr;6(4):343-51. doi: 10.1007/BF00963849.
In the present study, we examined the distribution of [3H]corticosterone ([3H]B) in chick embryonic brain during development using two different routes of administration: intracerebral and intraocular. After injection of 1 microCi into the brain of 8-day embryos, [3H]B was preferentially accumulated in the retinas, whereas regions such as cerebral hemispheres, optic tecta, and midbrain showed lower amounts of [3H]B. In 14-day embryos, a slightly higher amount of [3H]B was found in retinas and midbrain in comparison with other regions of the brain. After injection into the eye, [3H]B seemed to easily diffuse to brain regions and toe preferentially accumulate in the opposite eye and very slowly diffused to other brain areas. The accumulation of the hormone in the retina parallels the presence of hormone receptors reported by others. A correlation between the preferential accumulation of hormone and its action is proposed.
在本研究中，我们采用两种不同给药途径：脑内注射和眼内注射，研究了发育过程中鸡胚脑中[3H]皮质酮（[3H]B）的分布。向8日龄胚胎脑内注射1微居里[3H]B后，[3H]B优先积聚在视网膜中，而大脑半球、视顶盖和中脑等区域的[3H]B含量较低。在14日龄胚胎中，与脑的其他区域相比，视网膜和中脑中的[3H]B含量略高。注射到眼内后，[3H]B似乎很容易扩散到脑区，并优先积聚在对侧眼中，然后非常缓慢地扩散到其他脑区。激素在视网膜中的积聚与其他人报道的激素受体的存在情况相似。我们提出了激素的优先积聚与其作用之间的相关性。
