Meyniel D, Petit J, Bodin F, Poupon R, Darnis F
Nouv Presse Med. 1981 Jun 20;10(27):2281-4.
The megaloblastic anaemia observed in patients with chronic atrophic gastritis is usually due to malabsorption of vitamin B12. In some cases, the absence of intrinsic factor supports the diagnosis of pernicious anaemia but other factors, the importance of which varies from case to case, are also involved. They include proliferation of bacteria in the lumen of the gut, intestinal cell abnormalities resulting from lack of vitamin B12 and low hydrochloric acid output with subsequent reduction in the release of vitamin B12 from foodstuffs. With regard to treatment, it would seem justified to combine oral broad-spectrum antibiotics with parenteral administration of vitamin B12.
在患有慢性萎缩性胃炎的患者中观察到的巨幼细胞贫血通常是由于维生素B12吸收不良所致。在某些情况下，内因子缺乏支持恶性贫血的诊断，但其他因素（其重要性因病例而异）也参与其中。这些因素包括肠道腔内细菌的增殖、因缺乏维生素B12导致的肠道细胞异常以及胃酸分泌减少，随后食物中维生素B12的释放也减少。关于治疗，将口服广谱抗生素与维生素B12的胃肠外给药联合使用似乎是合理的。
