Central effects of prostaglandin D2.

In male Wistar rats PGD2 was injected introcerebroventricularly in a dose of 1, 10 or 50 microgram. PGD2 did not produce change in rat behavior and did not change the body temperature, blood pressure and respiration. PGD2 potentiated slightly the catalepsy elicited by chloropromazine or haloperidol, and in high dose had weak cataleptogenic effect. PGD2 changed the level of GABA i some brain areas. In general, however, the central effects of PGD2 are almost negligible.