Brus R, Herman Z S, Szklinik R
Pol J Pharmacol Pharm. 1980 Sep-Oct;32(5):681-4.
In male Wistar rats PGD2 was injected introcerebroventricularly in a dose of 1, 10 or 50 microgram. PGD2 did not produce change in rat behavior and did not change the body temperature, blood pressure and respiration. PGD2 potentiated slightly the catalepsy elicited by chloropromazine or haloperidol, and in high dose had weak cataleptogenic effect. PGD2 changed the level of GABA i some brain areas. In general, however, the central effects of PGD2 are almost negligible.
在雄性Wistar大鼠中，以1、10或50微克的剂量脑室内注射前列腺素D2（PGD2）。PGD2未引起大鼠行为改变，也未改变体温、血压和呼吸。PGD2轻微增强了氯丙嗪或氟哌啶醇引起的僵住症，且高剂量时具有微弱的致僵住症作用。PGD2改变了某些脑区的γ-氨基丁酸（GABA）水平。然而，总体而言，PGD2的中枢作用几乎可以忽略不计。
