寻找新型取代苯氧基乙酰亚乙胺作为可能的中枢神经系统、单胺氧化酶和抗惊厥药物。
Search for newer substituted phenoxyacetylethyleneimines as possible CNS, MAO and anticonvulsant agents.
作者信息
Shukla J S, Ahmad I
出版信息
Pharmazie. 1981 May;36(5):327-8.
PMID:7267680
Abstract
Various substituted phenoxyacetic acids were converted into the acid chlorides, which react with ethyleneimine in pyridine to give the desired product. These compounds were evaluated for central nervous system (CNS) activity. Some of the compounds at a concentration of 1 . 10-3mol/l inhibited rat brain monoamine oxidase (MAO) in vitro and provided protection against pentylenetetrazole-induced convulsions in mice.
摘要
各种取代苯氧基乙酸被转化为酰氯，酰氯在吡啶中与乙亚胺反应生成所需产物。对这些化合物进行了中枢神经系统（CNS）活性评估。其中一些化合物在浓度为1×10⁻³mol/L时，在体外能抑制大鼠脑单胺氧化酶（MAO），并对小鼠戊四氮诱导的惊厥有保护作用。
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