Ponzio G, Aglietta M, Piacibello W, De Marchi M, Carbonara A O
Ric Clin Lab. 1981 Apr-Jun;11(2):111-5. doi: 10.1007/BF02886709.
The hematological and cytogenetical studies of a case of atypical myeloproliferative disorder are reported. The patient displayed moderate leukocytosis, anemia and thrombocytopenia. Reduced or absent growth of CFU-C was observed in the bone marrow and peripheral blood. The cytogenetical analysis revealed a trisomy 21 limited to the neoplastic clone. The overall results are discussed and compared with the rare cases of acquired trisomy 21 reported in the literature.
报告了一例非典型骨髓增殖性疾病的血液学和细胞遗传学研究。患者表现为中度白细胞增多、贫血和血小板减少。在骨髓和外周血中观察到集落形成单位 - 粒细胞（CFU - C）生长减少或缺乏。细胞遗传学分析显示21三体仅限于肿瘤克隆。对总体结果进行了讨论，并与文献中报道的罕见获得性21三体病例进行了比较。
