Coles S M, Klein H G, Holland P V
Transfusion. 1981 Jul-Aug;21(4):462-6. doi: 10.1046/j.1537-2995.1981.21481276005.x.
A retrospective study was undertaken to determine the frequency of alloimmunization in two multitransfused patient populations. Three hundred eighteen unselected patients whose transfusion records were available were studied. One hundred fifty-seven patients had sickle cell disease (SCD) and 161 had thalassemia. Forty-four antibodies were detected in 23 of the 99 transfused SCD patients. The predominate antibodies were in the Rh group: seventeen were anti-rh"(E), eight were anti-rh'(C), and four were anti-rh'w(Cw). Of the remaining antibodies, five were anti-Kell, three were anti-Jka, two were anti-Jkb, three were anti-Fya, one was anti-Bga, and one was anti-S. In the thalassemic patients, six antibodies were detected in 4 of the 39 transfused patients. Of these, there were two anti-Kell and one anti-Rho (D), anti-rh'(C), anti-rh'w(Cw), and anti-Fya each. Although the SCD patients were more likely to have been transfused at the parent institution than were the thalassemic patients (69% vs. 24%, p less than 0.05), the frequencies of alloimmunized patients, the total number of antibodies, and the number of Rh antibodies did not differ significantly (p greater than 0.05) for transfused patients in the two populations.
进行了一项回顾性研究，以确定两个多次输血患者群体中同种免疫的发生率。研究了318名有输血记录的未经筛选的患者。其中157例患有镰状细胞病（SCD），161例患有地中海贫血。在99例接受输血的SCD患者中的23例检测到44种抗体。主要抗体属于Rh血型系统：17例为抗-rh”（E），8例为抗-rh’（C），4例为抗-rh’w（Cw）。其余抗体中，5例为抗-Kell，3例为抗-Jka，2例为抗-Jkb，3例为抗-Fya，1例为抗-Bga，1例为抗-S。在地中海贫血患者中，39例接受输血的患者中的4例检测到6种抗体。其中，2例为抗-Kell，各有1例为抗-Rho（D）、抗-rh’（C）、抗-rh’w（Cw）和抗-Fya。虽然SCD患者比地中海贫血患者在母机构输血的可能性更大（69%对24%，p<0.05），但两个群体中接受输血患者的同种免疫患者频率、抗体总数和Rh抗体数量没有显著差异（p>0.05）。
