Voskresenskiĭ O N, Bobyrev V N
Vopr Pitan. 1981 May-Jun(3):42-5.
The paper describes a procedure for reproduction of experimental peroxide atheroarteriosclerosis in rabbits by means of keeping the animals on a semi-natural antioxidant-free diet (casein, coconut oil, starch, sugar. extracted oats, dry yeast, straw, vitamins A and D, a mixture of salts). After 100 days of experimentation the mean area of the involved aorta constituted 72.9 +/- 6.1 %. The biochemical characteristics of experimental peroxide atheroarteriosclerosis is presented. The advantages of this model comparatively to the cholesterol and triglyceride-induced diseases are as follows: the similarity of the atherogenous diet to alimentary factors promoting atherosclerosis in man, endogenous nature of hypercholesterolemia and its moderate grade; development of destructive changes and calcinosis in the arteries in addition to lipidosis and fibrosis.
该论文描述了一种在兔子身上复制实验性过氧化物动脉粥样硬化的方法，即让动物食用半天然无抗氧化剂饮食（酪蛋白、椰子油、淀粉、糖、燕麦提取物、干酵母、稻草、维生素A和D、盐混合物）。经过100天的实验，受累主动脉的平均面积为72.9±6.1%。文中呈现了实验性过氧化物动脉粥样硬化的生化特征。该模型相对于胆固醇和甘油三酯诱导疾病的优势如下：致动脉粥样硬化饮食与促进人类动脉粥样硬化的饮食因素相似，高胆固醇血症的内源性及其程度适中；除脂肪变性和纤维化外，动脉还会出现破坏性变化和钙化。
