Bretlau P, Sørensen C H, Jørgensen M B, Dabelsteen E, Holmstrup P
Acta Otolaryngol. 1981 May-Jun;91(5-6):575-84.
A model for studying different aspects of human cholesteatomas in vivo and in the immunodeficient "nude" mouse is described. Epithelial-mesenchymal interaction was studied in human cholesteatoma membranes, transplanted to the flank region. Findings of cystic lesions lined by stratified keratinizing epithelium were frequent, and the connective tissue reaction was weak. Furthermore, human cholesteatoma membranes were transplanted into the middle ear cavity of 'nude' mice. After 21-28 days, bone resorption was found in the labyrinthine capsule, but not always with signs of inflammation.
描述了一种用于在体内和免疫缺陷的“裸”小鼠中研究人类胆脂瘤不同方面的模型。将人类胆脂瘤膜移植到侧腹区域，研究上皮-间充质相互作用。经常发现有由复层角化上皮衬里的囊性病变，结缔组织反应较弱。此外，将人类胆脂瘤膜移植到“裸”小鼠的中耳腔。21至28天后，在迷路囊发现骨吸收，但并非总是伴有炎症迹象。
