Bretlau P, Sørensen C H, Jørgensen M B, Dabelsteen E, Holmstrup P
Acta Otolaryngol Suppl. 1984;414:178-85. doi: 10.3109/00016488409122902.
A model for studying different aspects of human cholesteatomas in vivo in the immunodeficient "nude' mice is described. Epithelial-mesenchymal interaction was studied in human cholesteatoma membranes, transplanted to the flank region. Findings of cystic lesions lined by stratified keratinizing epithelium were frequent and the connective tissue reaction were weak. Furthermore human cholesteatomy membranes were transplanted into the middle ear cavity of the "nude' mice. After 21-28 days bone resorption was shown in the labyrinthine capsule, not always with sign of inflammation.
描述了一种在免疫缺陷的“裸”鼠体内研究人胆脂瘤不同方面的模型。在移植到胁腹区域的人胆脂瘤膜中研究上皮-间充质相互作用。经常发现有由复层角化上皮衬里的囊性病变，且结缔组织反应较弱。此外，将人胆脂瘤膜移植到“裸”鼠的中耳腔。21至28天后，在迷路囊出现骨吸收，并不总是伴有炎症迹象。
