Parnham M J
Agents Actions. 1980 Dec;10(6):495-8. doi: 10.1007/BF02024149.
The pannus of rheumatoid arthritis is a proliferating mass of various cells and tissues, including follicles of lymphoid cels, and is the major agent of destruction of the surrounding structural tissues. Infiltrating lymphocytes are thought to be the prime stimuli for the growth of the pannus, through the secretion of of lymphokines. In contrast to this high turnover, destructive rheumatoid granuloma, most commonly used experimental granuloma models are of the non-immune, low turnover variety and thus give a rather poor reflection of clinical conditions. A model has been developed in our laboratory in which lymph node cells are removed from Freund's complete adjuvant sensitized rats and injected into sponge implants in normal syngeneic recipient animals, leading to enhancement of granuloma formation. This response has been characterized and shown to be related to lymphocyte activation and to the sensitivity of rats to polyarthritis induction. The lymphocyte transfer model may be useful in studying the action of drugs on lymphocyte mediated chronic inflammatory responses and the principle of lymphocyte transfer may be applied to other hypersensitivity granuloma models.
类风湿关节炎的血管翳是由各种细胞和组织构成的增生性肿块，包括淋巴细胞滤泡，是周围结构组织破坏的主要因素。浸润的淋巴细胞被认为是血管翳生长的主要刺激因素，通过分泌淋巴因子起作用。与这种高周转率的、具有破坏性的类风湿肉芽肿相反，最常用的实验性肉芽肿模型是非免疫性的、低周转率类型的，因此对临床情况的反映相当差。我们实验室已经开发出一种模型，从弗氏完全佐剂致敏的大鼠中取出淋巴结细胞，注入同基因正常受体动物的海绵植入物中，导致肉芽肿形成增强。这种反应已得到表征，并表明与淋巴细胞活化以及大鼠对多关节炎诱导的敏感性有关。淋巴细胞转移模型可能有助于研究药物对淋巴细胞介导的慢性炎症反应的作用，并且淋巴细胞转移的原理可能适用于其他超敏性肉芽肿模型。
