Eugui E M, Houssay R H
Immunology. 1975 Apr;28(4):703-10.
Pretreatment of rats with subarthritogenic doses of mycobacterial adjuvant suppresses the arthritogenic reaction induced by this adjuvant. This unresponsiveness can betransferred to normal syngeneic recipients by viable lymph node cells from unresponsivedonors. Serum from the same donors did not prevent the arthritis. Abrogation ofunresponsiveness was obtained by injecting normal lymph node cells together with the challeging inoculation and also with sensitized lymphoid cells. In agreement with the concept of tolerance as an active immune reaction, the data suggest that in this experimental model lymphoid cells actively suppress the immune response induced by microbacterial adjuvant. Thus, arthritis or unresponsiveness may result from the predominance of either sensitized or suppressor cells.
用亚致关节炎剂量的分枝杆菌佐剂对大鼠进行预处理，可抑制该佐剂诱导的致关节炎反应。这种无反应性可通过来自无反应供体的活淋巴结细胞转移给正常的同基因受体。来自相同供体的血清不能预防关节炎。通过将正常淋巴结细胞与激发接种物以及致敏淋巴细胞一起注射，可消除无反应性。与耐受性作为一种主动免疫反应的概念一致，数据表明在该实验模型中，淋巴细胞可积极抑制由微生物佐剂诱导的免疫反应。因此，关节炎或无反应性可能是由于致敏细胞或抑制细胞占优势所致。
