Novotny N M, Zetterman R K, Antonson D L, Vanderhoof J A
Am J Gastroenterol. 1981 Jun;75(6):449-50.
A previously undescribed variation in liver histology was observed in association with syndromatic neonatal jaundice, otherwise known as Alagille's syndrome. While hepatic ductular hypoplasia is thought to be characteristic of this disorder, we observed a patient who had all of the characteristic morphological features of Alagille's syndrome but whose liver biopsy demonstrated marked ductular proliferation more characteristic of biliary atresia. This histological feature has not been previously reported with Alagille's syndrome and hepatic ductular hypoplasia can no longer be considered characteristic of syndromatic neonatal jaundice.
在伴有综合征性新生儿黄疸（即阿拉吉耶综合征）的病例中，观察到一种此前未描述过的肝脏组织学变异。虽然肝内小胆管发育不全被认为是这种疾病的特征，但我们观察到一名患者，其具有阿拉吉耶综合征的所有特征性形态学表现，但其肝脏活检显示出更具胆道闭锁特征的明显小胆管增生。这种组织学特征此前尚未见阿拉吉耶综合征的相关报道，肝内小胆管发育不全也不能再被视为综合征性新生儿黄疸的特征。
