Jester J V, Steel D, Salz J, Miyashiro J, Rife L, Schanzlin D J, Smith R E
Am J Ophthalmol. 1981 Aug;92(2):153-71. doi: 10.1016/0002-9394(81)90764-9.
We performed a prospective study of the effects of radial keratotomy in the owl monkey. We compared a 16-incision and an eight-incision radial keratotomy, and followed the changes in corneal curvature, corneal thickness, endothelial cell counts, and intraocular pressure. We compared the results of the changes in these clinical factors with a histopathologic and ultrastructural analysis of the time-related changes after radial keratotomy in another group of animals. We found that the loss of initial corneal flattening following radial keratotomy corresponded with the contracture of the wound as demonstrated by histopathologic and ultrastructural study. This procedure results in a significant endothelial cell loss (14% to 15%), which is a result of the postsurgical inflammation associated with this surgery. Additionally, examination of the histopathologic structure of these corneas showed a high level of variability in the surgical incision depth, which we believe is responsible for the marked variations in the response to the surgical procedure.
我们对猫头鹰猴行放射状角膜切开术的效果进行了一项前瞻性研究。我们比较了16切口和8切口放射状角膜切开术，并跟踪角膜曲率、角膜厚度、内皮细胞计数和眼压的变化。我们将这些临床因素的变化结果与另一组动物放射状角膜切开术后时间相关变化的组织病理学和超微结构分析进行了比较。我们发现，放射状角膜切开术后最初角膜变平的丧失与伤口挛缩相对应，这在组织病理学和超微结构研究中得到了证实。该手术导致显著的内皮细胞损失（14%至15%），这是该手术相关的术后炎症的结果。此外，对这些角膜组织病理学结构的检查显示手术切口深度存在高度变异性，我们认为这是导致手术反应显著差异的原因。
