Etingova N I
Antibiotiki. 1981 Jun;26(6):414-9.
The process of solubilization of polyenic antibiotics, such as amphotericin B, mycoheptin, levorin and nystatin in aqueous solutions of sodium salts of bile acids: desoxycholic, cholic and dehydrocholic was studied. It was shown that amphotericin B and mycoheptin had the highest capacity for solubilization. No solubilization of the antibiotics was observed in the solutions of sodium dehydrocholate. Thermodynamic estimation of the solubilization process with sodium desoxycholate is presented.
研究了多烯类抗生素（如两性霉素B、抗霉菌素、利弗菌素和制霉菌素）在胆汁酸钠（脱氧胆酸钠、胆酸钠和脱氢胆酸钠）水溶液中的增溶过程。结果表明，两性霉素B和抗霉菌素的增溶能力最强。在脱氢胆酸钠溶液中未观察到抗生素的增溶现象。给出了用脱氧胆酸钠进行增溶过程的热力学估算。
